Fri Jul 29 2022

16 articles - From Friday Jul 22 2022 to Friday Jul 29 2022

parm_toc.knit

Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Pancreatology

Systematic review and meta-analysis: Diagnostic performance of DNA alterations in pancreatic juice for the detection of pancreatic cancer.

This meta-analysis shows that, in pancreatic juice, the presence of distinct DNA mutations (TP53, SMAD4 or CDKN2A) and NPTX2 hypermethylation have a high specificity (close to 100%) for the presence of high-grade dysplasia or pancreatic cancer. However, the sensitivity of these DNA alterations is poor to moderate, yet may increase if they are combined in a panel.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial.

Krill oil was safe to consume and resulted in modest improvements in knee pain, stiffness, and physical function in adults with mild to moderate knee OA.

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Next generation smartwatches to estimate whole body composition using bioimpedance analysis: accuracy and precision in a diverse multiethnic sample.

After systematic correction, smart watch BIA devices are capable of stable, reliable and accurate body composition with precision comparable but lower than laboratory measures. These devices allow for measurement in environments not accessible to laboratory systems such as the home, training centers, and geographically remote locations.

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Liver Transpl

MELD/PELD Exception Policy and Outcomes in Pediatric Patients with Hepatopulmonary Syndrome Requiring Liver Transplantation.

MELD/PELD exception for children with HPS mitigated waitlist mortality, and recipients with HPS experience excellent 5-year survival post-LT, though slightly lower than in patients without HPS. Unlike adults with HPS, severity of pre-LT hypoxemia in children does not impact post-LT survival. These data suggest that adult criteria for granting MELD/PELD exception points may not appropriately capture HPS severity in pediatric patients. Further prospective multicenter studies to examine risk factors predicting negative survival outcomes in children with HPS are warranted.

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Pancreas

Machine Learning for Computed Tomography Radiomics: Prediction of Tumor-Infiltrating Lymphocytes in Patients With Pancreatic Ductal Adenocarcinoma.

The XGBoost-based model could predict PDAC TILs and may facilitate clinical decision making for immune therapy.

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Treatment and Prevention of Intraabdominal Bleeding in Necrotizing Pancreatitis Patients Treated With a Step-Up Approach.

Bleeding events in NP patients treated with a MIS approach are associated with a 6-fold increase in mortality. Endovascular intervention is an effective strategy for the management of bleeding events. Prophylactic embolization may be an effective technique for reducing bleeding complications.

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Urine Proteomics Reveals Sex-Specific Response to Total Pancreatectomy With Islet Autotransplantation.

We found distinct changes in the urinary proteomic profile after TPIAT and the response to TPIAT is highly sex-specific.

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Pancreatology

Application of metagenomic next-generation sequencing for suspected infected pancreatic necrosis.

With more valuable diagnostic performance and shorter turnaround time, clinical mNGS represents a potential step forward in the early diagnosis of IPN.

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Long-term outcomes of patients with multifocal intraductal papillary mucinous neoplasm following pancreatectomy.

In patients with MF-IPMNs, each cyst should be evaluated individually for the presence of features associated with malignancy.

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Rectal INdomethacin, oral TacROlimus, or their combination for the prevention of post-ERCP pancreatitis (INTRO Trial): Protocol for a randomized, controlled, double-blinded trial.

The INTRO trial will assess the role of calcineurin inhibitors in PEP prophylaxis and develop a foundation for the clinical optimization of this therapeutic strategy from a pharmacologic and economic standpoint. With this clinical trial, we hope to demonstrate a novel approach to PEP prophylaxis using a widely available and well-characterized class of drugs.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Pancreatology

A review of the rationale for the testing of the calcineurin inhibitor tacrolimus for post-ERCP pancreatitis prevention.

In this review, we will firstly summarize data in support of testing the use of tacrolimus for PEP prophylaxis, either in combination with rectal indomethacin or by itself. Secondly, we propose that administering tacrolimus through the rectal route could be favorable for PEP prophylaxis over other routes of administration.

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Letters&Replies

Letters to the editors and authors’ replies

Pancreatology

Cartridge-based nucleic acid amplification test adds to an endosonographic diagnosis of pancreatic tuberculosis: A series from tuberculosis endemic region.

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Others

all remaining publications eg case reports, images of the month, etc…

Am J Clin Nutr

Can krill oil from small crustaceans be a panacea that alleviates symptoms of knee osteoarthritis?

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Could increasing inequalities in energy intake partly explain the increasing prevalence of obesity despite a leveling mean intake?

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Reply to T Kalayjian and EC Westman.

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Liver Transpl

Ultra Rapid Whole Genome Sequencing: A Paradigm Shift in the Pre-Transplant Evaluation of Neonatal Acute Liver Failure.

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